CITOTOXICIDAD EN CÉLULAS HELA DE EXTRACTOS DE TRES ESPECIES DE PLANTAS MEDICINALES DE HIDALGO, MÉXICO

Abstract

Ethanolic extracts of three medicinal plants,
Juniperus deppeana, Solanum rostratum
and Bidens odorata, which are used in
folk medicine in Hidalgo, Mexico, for the
treatment of wounds, ulcers, tumors and
cancer, were tested in a HeLa cell line to
evaluate their cytotoxic activity. The highest
cytotoxicity was found in the extract of J.
deppeana (IC50 = 4.63 μg/ml); hence, this
extract was separated via chromatography
on a silica gel plate, from which the main
fraction (Rf = 0.28) showed strong cytotoxic activity (IC50 = 0.79 μg/ml). Whereas
the extract of S. rostratum also exhibited
cytotoxicity (IC50 = 127.5 μg/ml), that of
B. odorata was inactive.